Welcome to PATH Builder

PATH (Preclinical Assessment of Translation to Humans) is a structured approach for presenting a comprehensive, accurate and transparent scientific rationale for early phase clinical trials and innovative care. Read the PATH paper (Kimmelman et al, 2024) for a detailed rationale and worked examples.

Open a PATH previously saved to your computer

Confirm view example PATH

Confirm start new PATH

Save and export options

Save this PATH as a JSON and you will be able to edit it again using PATH Builder

SVG export will only include the image of the PATH figure

Word export will only include the text of the PATH summary

Define your target scenario

The main task for assessing a proposal is to determine the level of confidence that a drug, when given to a target population, will produce a desired response. We call this the "target scenario."

Evidence for

References

Confirm delete evidence

Confirm delete reference

Start a new PATH with guidance

The following buttons will open guides for using the PATH approach in different situations:

PATH Builder Preclinical Assessment of Translation to Humans

Direct steps Translational steps Model steps Rx (D0) Rx (M0) T1 Molecular (D1) Molecular (M1) T2 Physiological (D2) Physiological (M2) T3 Clinical (D3) Clinical (M3)

Target scenario

No target scenario has been specified

Target modulation in models (M0-M1)

No evidence
Strong evidence

Translatability of molecular/target effects (T1)

No evidence
Strong evidence

Physiological effect in models (M1-M2)

No evidence
Strong evidence

Translatability of pathophysiological effects (T2)

No evidence
Strong evidence

Clinical effect in models (M2-M3)

No evidence
Strong evidence

Translatability of clinical/functional effects (T3)

No evidence
Strong evidence

Target modulation in the target scenario (D0-D1)

No evidence
Strong evidence

Physiological effect in the target scenario (D1-D2)

No evidence
Strong evidence

Clinical effect in the target scenario (D2-D3)

No evidence
Strong evidence

References