PATH (Preclinical Assessment of Translation to Humans) is a structured approach for presenting a comprehensive, accurate and transparent scientific rationale for early phase clinical trials and innovative care. Read the PATH paper (Kimmelman et al, 2024) for a detailed rationale and worked examples.
Open a PATH previously saved to your computer
This will replace the PATH that you currently have loaded with the data from the selected file. Are you sure?
Confirm view example PATH
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Confirm start new PATH
Are you sure you want to clear the PATH that you currently have loaded? You will lose any unsaved work.
Save and export options
Save this PATH as a JSON and you will be able to edit it again using PATH Builder
SVG export will only include the image of the PATH figure
Word export will only include the text of the PATH summary
Define your target scenario
The main task for assessing a proposal is to determine the level of confidence that a drug, when given to a target population, will produce a desired response. We call this the "target scenario."
Evidence for
References
Confirm delete evidence
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Rate strength of evidence
No evidence
Strong evidence
Start a new PATH with guidance
The following buttons will open guides for using the PATH approach in different situations:
PATH Builder
Preclinical Assessment of Translation to Humans
Target scenario
No target scenario has been specified
Target modulation in models (M0-M1)
Translatability (T1)
Physiological effect in models (M1-M2)
Translatability (T2)
Clinical effect in models (M2-M3)
Translatability (T3)
Target modulation in the target scenario (D0-D1)
Physiological effect in the target scenario (D1-D2)